Proven Effectiveness in Treating Depression
Provided Efficacy Similar to SSRIs in Major Depressive Disorder
In 5 head-to-head studies, with more than 1,900 cumulative patients, bupropion was found to be similarly effective as the SSRIs Lexapro,
Zoloft, and Prozac*1-5
- - Based on HAM-D-17 total score analysis at treatment week 8
- Studies evaluated the mean change in HAM-D scores and were
conducted using bupropion HCl sustained-release tablets.
American Psychiatric Association practice guidelines state that effectiveness of antidepressants is generally
comparable, so choosing an antidepressant is typically based on other factors, including anticipated side effects.6
WELLBUTRIN XL may cause serious side effects. The most
common side effects of WELLBUTRIN XL include:
- Dry mouth
- Nausea and vomiting
- Trouble sleeping
- Shakiness (tremor)
- Fast heartbeat
- Heavy sweating
If you have nausea, take your medicine with food. If you
have trouble sleeping, do not take your medicine too close to bedtime.
Tell your healthcare provider right away about any side
effects that bother you.
These are not all the possible side effects of
WELLBUTRIN XL. For more information, ask your healthcare
provider or pharmacist.
A Common Problem With Depression Treatment
Risk of Sexual Side Effects With Some Antidepressants
Antidepressant use is associated with a number of possible side effects, including sexual side effects (such as loss of
sex drive, inability to become aroused or difficulty achieving sexual satisfaction), which can affect both men and
Sexual side effects may start early-problems may appear within a week of starting treatment with some
Significantly fewer patients taking WELLBUTRIN XL® had difficulty achieving sexual satisfaction compared with patients taking LEXAPRO† (escitalopram). In fact, among patients taking bupropion SR, this problem was not
statistically different than with placebo (sugar pill)4
Problems achieving sexual satisfaction were significantly more common among patients taking PROZAC
(fluoxetine), than among those taking bupropion SR or placebo (sugar pill)1,5
In an 8 week study, patients treated with bupropion SR were significantly less likely to experience a loss in sexual
desire than patients taking ZOLOFT† (sertraline)3
Your doctor can't help if you don't speak up about sexual side effects-in one study of 344 patients, 58% of the
patients taking the most commonly prescribed antidepressants were having sexual side effects when asked by their
doctor, but only 14% had mentioned them to their doctor.6† There's no need to be shy-the American Psychiatric
Association encourages doctors to discuss sexual side effects with patients to help determine a cause and a solution
to the problem7
†Only the following SSRIs were included in this study: fluoxetine, fluvoxamine, paroxetine, sertraline. Sexual dysfunction includes
loss of sex drive, inability to become aroused, and problems achieving sexual satisfaction.
How to take WELLBUTRIN XL®
- Take WELLBUTRIN XL exactly as prescribed by your healthcare provider.
- Do not chew, cut, or crush WELLBUTRIN XL tablets.
- Take WELLBUTRIN XL at the same time each day.
- Take your doses of WELLBUTRIN XL at least 24 hours apart.
- You may take WELLBUTRIN XL with or without food.
- If you miss a dose, do not take an extra tablet to make up for the dose you missed. Wait and take your next tablet at the regular time. This is very important. Too much WELLBUTRIN XL can increase your chance of having a seizure
- If you take too much WELLBUTRIN XL, or overdose, call your local emergency room or poison control center right away.
- Do not take any other medicines while using WELLBUTRIN XL unless your healthcare provider has told you it is okay.
- Do not change your dose or stop taking WELLBUTRIN XL without first talking with your healthcare provider.