HomeMost Common Side Effects Are Manageable
The most common adverse reactions that occurred in controlled clinical trials in at least 5% of patients treated with bupropion HCl sustained-release (300 and 400 mg per day) and at a rate at least twice the placebo rate were1:
- Dry mouth
- Nausea
- Insomnia
- Dizziness
- Pharyngitis
- Abdominal pain
- Agitation
- Anxiety
- Tremor
- Palpitation
- Sweating
- Tinnitus
- Myalgia
- Anorexia
- Urinary frequency
- Rash
WELLBUTRIN bioequivalence has been established across immediate-, sustained-, and extended-release formulations.1
The American Psychiatric Association practice guidelines state that anticipated side effects are a key factor in choosing the optimal antidepressant therapy for each patient.3
References:
- WELLBUTRIN XL (bupropion hydrochloride extended-release) Prescribing Information. 2017. Bausch Health Companies Inc.
- Modell JG, Rosenthal NE, Harriett AE, et al. Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. 2005;58(8):658-667.
- Gelenberg AJ, Freeman MP, Markowitz JC, et al. Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association. Am J Psychiatry. 2000;157(4 suppl):1-45.
- Clayton AH, Croft HA, Horrigan JP, et al. Bupropion extended release compared with escitalopram: effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies. J Clin Psychiatry. 2006;67(5):736-746.
Low Risk of Weight Gain
Low Risk of Orgasm Dysfunction
MDD, major depressive disorder;
SAD, seasonal affective disorder.
INDICATION
WELLBUTRIN XL® (bupropion hydrochloride extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).
IMPORTANT SAFETY INFORMATION
WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS
Suicidal Thoughts or Actions and Antidepressant Drugs
Antidepressants may increase the risk of suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Depression or other serious mental illnesses are the most important causes of suicidal thoughts and actions. People who have (or have a family history of) bipolar illness or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. WELLBUTRIN XL has not been evaluated for use in patients under the age of 18.