WELLBUTRIN XL is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).1

WELLBUTRIN XL belongs to a class of medications called NDRI, which is also known as norepinephrine-dopamine reuptake inhibitors. It works on chemicals in your brain that affect mood.1-3

Generic versions of WELLBUTRIN XL may contain different inactive ingredients. While inactive ingredients do not affect how well a medicine works, they may cause different side effects.4,5

Also, due to the variety of different WELLBUTRIN XL generics, you could get a pill one month that looks, smells, and/or tastes different than the pill from the month before.4,6

Another difference is SmartCoatTM technology. Only brand name WELLBUTRIN XL has this patented technology, allowing steady release of each dose. This means a consistent level of the active ingredient is available in the body over the course of each day.7-9

The most common side effects of WELLBUTRIN XL include trouble sleeping, feeling anxious, stuffy nose, nausea, dry mouth, constipation, dizziness, and joint aches.1

Often common side effects of antidepressants go away after the first few weeks of treatment. Talk to your doctor about any side effects you have.10,11

Pharmacy/Access Support

First, tell your doctor you want brand name WELLBUTRIN XL. Ask your doctor to write DAW1 or “brand medically necessary” on the prescription. DAW1 means “dispense as written.”

When you go to pick up your prescription, check it before leaving the pharmacy. Brand name WELLBUTRIN XL is a creamy white to pale yellow round tablet that has “WELLBUTRIN XL” on it followed by the dose.1

If you find that your prescription has been substituted for a generic, ask to speak to the pharmacist so that he or she can confirm that your doctor authorized the substitution.

Your healthcare provider may need to fill out what is called a prior authorization form in order for your insurance to cover the brand name. Find out more about prior authorization.

You can also ask your doctor to send your prescription to PhilRx. They can work with your insurance to get prior authorization approval and coordinate delivery of your prescription to your home, for free! Find out more about PhilRx.

Yes! Most eligible* commercially insured patients can enroll for Copay Savings and pay as low as $5 for each 30-day supply. Learn more about Copay Savings.

*Maximum benefits apply. Additional terms and conditions apply. For full eligibility requirements, please see Savings & Support tab above.

  1. WELLBUTRIN XL (bupropion hydrochloride extended-release) Prescribing Information. Bausch Health Companies Inc.
  2. National Institute of Mental Health. Depression. https://www.nimh.nih.gov/health/topics/depression/index.shtml. Accessed November 12, 2020.
  3. U.S. Food & Drug Administration. Depression: FDA-approved medications may help. https://www.fda.gov/consumers/consumer-updates/depression-fda-approved-medications-may-help. Accessed November 12, 2020.
  4. Straka RJ, Keohane DJ, Liu LZ. Potential clinical and economic impact of switching branded medications to generics. Am J Ther. 2017;24(3):e278-e289.
  5. Brown T. Inactive ingredients in medications cause trouble for some. https://www.medscape.com/viewarticle/910411. Accessed November 12, 2020.
  6. Peters JR. From our perspective: the importance of the physical characteristics of generic drugs. U.S. Food & Drug Administration. https://www.fda.gov/drugs/newsevents/ucm471446.htm. Accessed November 12, 2020.
  7. Fava M, Rush AJ, Thase ME, et al. 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry. 2005;7(3):106-113.
  8. US Patent 6096341.
  9. US Patent 6143327.
  10. Mayo Clinic. Bupropion (oral route). https://www.mayoclinic.org/drugs-supplements/bupropion-oral-route/description/drg-20062478. Accessed November 12, 2020.
  11. InformedHealth.org. Depression: how effective are antidepressants? https://www.ncbi.nlm.nih.gov/books/NBK361016/?report=printable. Accessed November 12, 2020.