HomeMost Common Side Effects Are Manageable
The most common adverse reactions that occurred in controlled clinical trials in at least 5% of patients treated with bupropion HCl sustained-release (300 and 400 mg per day) and at a rate at least twice the placebo rate were1:
- Dry mouth
- Nausea
- Insomnia
- Dizziness
- Pharyngitis
- Abdominal pain
- Agitation
- Anxiety
- Tremor
- Palpitation
- Sweating
- Tinnitus
- Myalgia
- Anorexia
- Urinary frequency
- Rash
WELLBUTRIN bioequivalence has been established across immediate-, sustained-, and extended-release formulations.1
The American Psychiatric Association practice guidelines state that anticipated side effects are a key factor in choosing the optimal antidepressant therapy for each patient.3
References:
- WELLBUTRIN XL (bupropion hydrochloride extended-release) Prescribing Information. 2017. Bausch Health Companies Inc.
- Modell JG, Rosenthal NE, Harriett AE, et al. Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. 2005;58(8):658-667.
- Gelenberg AJ, Freeman MP, Markowitz JC, et al. Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association. Am J Psychiatry. 2000;157(4 suppl):1-45.
- Clayton AH, Croft HA, Horrigan JP, et al. Bupropion extended release compared with escitalopram: effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies. J Clin Psychiatry. 2006;67(5):736-746.
Low Risk of Weight Gain
Low Risk of Orgasm Dysfunction
MDD, major depressive disorder;
SAD, seasonal affective disorder.