Experience an Established Safety Profile

In clinical trials...

More than


of patients stayed
on treatment1,2*

Most Common Side Effects Are Manageable

The most common adverse reactions that occurred in controlled clinical trials in at least 5% of patients treated with bupropion HCl sustained-release (300 and 400 mg per day) and at a rate at least twice the placebo rate were1:

  • Dry mouth
  • Nausea
  • Insomnia
  • Dizziness
  • Pharyngitis
  • Abdominal pain
  • Agitation
  • Anxiety
  • Tremor
  • Palpitation
  • Sweating
  • Tinnitus
  • Myalgia
  • Anorexia
  • Urinary frequency
  • Rash

WELLBUTRIN bioequivalence has been established across immediate-, sustained-, and extended-release formulations.1

The American Psychiatric Association practice guidelines state that anticipated side effects are a key factor in choosing the optimal antidepressant therapy for each patient.3
  1. WELLBUTRIN XL (bupropion hydrochloride extended-release) Prescribing Information. 2017. Bausch Health Companies Inc.
  2. Modell JG, Rosenthal NE, Harriett AE, et al. Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. 2005;58(8):658-667.
  3. Gelenberg AJ, Freeman MP, Markowitz JC, et al. Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association. Am J Psychiatry. 2000;157(4 suppl):1-45.
  4. Clayton AH, Croft HA, Horrigan JP, et al. Bupropion extended release compared with escitalopram: effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies. J Clin Psychiatry. 2006;67(5):736-746.

Low Risk of Weight Gain

Wellbutrin weight gain

Low Risk of Orgasm Dysfunction

Wellbutrin orgasm dysfunction

MDD, major depressive disorder;
SAD, seasonal affective disorder.