
What is WELLBUTRIN XL?
WELLBUTRIN XL is a prescription medicine used to treat adults with major depressive disorder and for the prevention of seasonal affective disorder.1
Only brand-name WELLBUTRIN XL offers SmartCoatTM technology with steady 24-hour coverage2-4
WELLBUTRIN XL’s patented SmartCoat technology ensures a steady release of medication throughout the day, providing consistent coverage for 24 hours.
Outer coating protects against moisture
Inner coating provides a steady release of WELLBUTRIN XL over 24 hours


Inner coating provides a steady release of WELLBUTRIN XL over 24 hours

WELLBUTRIN XL tablets come in 2 dosage strengths to support your needs1

150 mg

300 mg
Graphic representation of WELLBUTRIN XL. Not actual size.
How to take WELLBUTRIN XL
WELLBUTRIN XL is taken once daily in the morning, with or without food1

Dosing
guidelines1

Swallow tablets whole. Do not chew, cut, or crush them.

Do not change your dose or stop taking WELLBUTRIN XL without talking with your healthcare provider first.

Do not take an extra tablet to make up for a missed dose. Wait until the next day to take your dose at the regular time. This is important. Too much WELLBUTRIN XL can increase your chance of having a seizure.

It's important to take WELLBUTRIN XL exactly as prescribed by your healthcare provider.
WELLBUTRIN XL side effects
WELLBUTRIN XL has a well-established safety profile
In clinical trials, about 90% of study participants stayed on treatment.1,5*
Common side effects of WELLBUTRIN XL include1:
- Trouble sleeping
- Stuffy nose
- Dry mouth
- Dizziness
- Feeling anxious
- Nausea
- Constipation
- Joint aches
*Based on 376 patients taking 300 mg/day of bupropion hydrochloride sustained-release in MDD and 537 patients on bupropion hydrochloride extended-release in SAD; compared with 96% of 385 patients on placebo in MDD trials and 95% of 511 patients on placebo in SAD trials.1,5
Please see additional Important Safety Information on right side bar.Low incidence of weight gain with WELLBUTRIN XL*
Weight gain is a frequent concern for patients prescribed an antidepressant. This was not a common side effect in clinical trials with WELLBUTRIN XL.1,6-10
Weight gain (≥5 lbs) observed in MDD trials of up to 6 weeks1
Patients on 300 mg daily
3%gained ≥5 lbs
Based on 339 patients compared to
4% of 347 patients on placebo.†
Patients on 400 mg daily
2%gained ≥5 lbs
Based on 112 patients compared to
4% of 347 patients on placebo.†

Talk to your healthcare provider if you experience any side effects that bother you or do not go away.
*WELLBUTRIN XL is not indicated for weight loss.
†Patients in the clinical trials received the sustained-release formulation of buproprion hydrochloride.
Please see additional Important Safety Information on right side bar.Low incidence of sexual side effects with WELLBUTRIN XL*
Orgasm dysfunction is a frequent concern for patients prescribed an antidepressant. This was not a common side effect in clinical trials with WELLBUTRIN XL.6-11
Percentage of patients with orgasm dysfunction in
MDD clinical trials after 8 weeks of treatment11
Escitalopram
VS.
WELLBUTRIN XL
Data combined from 2 MDD clinical studies of 397 patients receiving escitalopram and 388 patients receiving WELLBUTRIN XL.

Talk to your healthcare provider if you experience any side effects that bother you or do not go away.

Talk to your healthcare provider if you experience any side effects that bother you or do not go away.
MDD, major depressive disorder; SAD, seasonal affective disorder.
WELLBUTRIN XL side effects
WELLBUTRIN XL has a well-established safety profile
In clinical trials, about 90% of study participants stayed on treatment.1,5*
Common side effects of WELLBUTRIN XL include1:
- Trouble sleeping
- Stuffy nose
- Dry mouth
- Dizziness
- Feeling anxious
- Nausea
- Constipation
- Joint aches
*Based on 376 patients taking 300 mg/day of bupropion hydrochloride sustained-release in MDD and 537 patients on bupropion hydrochloride extended-release in SAD; compared with 96% of 385 patients on placebo in MDD trials and 95% of 511 patients on placebo in SAD trials.1,5
Please see additional Important Safety Information below.
WELLBUTRIN XL has a well-established safety profile
In clinical trials, about 90% of study participants stayed on treatment.1,5*
Common side effects of WELLBUTRIN XL include1:
- Trouble sleeping
- Stuffy nose
- Dry mouth
- Dizziness
- Feeling anxious
- Nausea
- Constipation
- Joint aches
*Based on 376 patients taking 300 mg/day of bupropion hydrochloride sustained-release in MDD and 537 patients on bupropion hydrochloride extended-release in SAD; compared with 96% of 385 patients on placebo in MDD trials and 95% of 511 patients on placebo in SAD trials.1,5
Please see additional Important Safety Information below.
Low incidence of weight gain with WELLBUTRIN XL*
Weight gain is a frequent concern for patients prescribed an antidepressant. This was not a common side effect in clinical trials with WELLBUTRIN XL.1,6-10
Weight gain (≥5 lbs) observed in MDD trials of up to 6 weeks1
Patients on 300 mg daily
3%
gained ≥5 lbs
Based on 339 patients compared to
4% of 347 patients on placebo.†
Patients on 400 mg daily
2%
gained ≥5 lbs
Based on 112 patients compared to
4% of 347 patients on placebo.†
*WELLBUTRIN XL is not indicated for weight loss.
†Patients in the clinical trials received the sustained-release formulation of buproprion hydrochloride.
Please see additional Important Safety Information below.
Low incidence of weight gain with WELLBUTRIN XL*
Weight gain is a frequent concern for patients prescribed an antidepressant. This was not a common side effect in clinical trials with WELLBUTRIN XL.1,6-10
Weight gain (≥5 lbs) observed in MDD trials of up to 6 weeks1
Patients on 300 mg daily
3%gained ≥5 lbs
Based on 339 patients compared to
4% of 347 patients on placebo.†
Patients on 400 mg daily
2%gained ≥5 lbs
Based on 112 patients compared to
4% of 347 patients on placebo.†
*WELLBUTRIN XL is not indicated for weight loss.
†Patients in the clinical trials received the sustained-release formulation of buproprion hydrochloride.
Please see additional Important Safety Information below.
Low incidence of sexual side effects with WELLBUTRIN XL*
Orgasm dysfunction is a frequent concern for patients prescribed an antidepressant. This was not a common side effect in clinical trials with WELLBUTRIN XL.6-11
Percentage of patients with orgasm dysfunction in
MDD clinical trials after 8 weeks of treatment11
30%
Escitalopram
VS.
15%
WELLBUTRIN XL
Data combined from 2 MDD clinical studies of 397 patients receiving escitalopram and 388 patients receiving WELLBUTRIN XL.
Please see additional Important Safety Information below.
Low incidence of sexual side effects with WELLBUTRIN XL*
Orgasm dysfunction is a frequent concern for patients prescribed an antidepressant. This was not a common side effect in clinical trials with WELLBUTRIN XL.6-11
Percentage of patients with orgasm dysfunction in
MDD clinical trials after 8 weeks of treatment11
Escitalopram
VS.
WELLBUTRIN XL
Data combined from 2 MDD clinical studies of 397 patients receiving escitalopram and 388 patients receiving WELLBUTRIN XL.
Please see additional Important Safety Information below.

Talk to your healthcare provider if you experience any side effects that bother you or do not go away.
MDD, major depressive disorder; SAD, seasonal affective disorder.
REFERENCES:
- WELLBUTRIN XL (bupropion hydrochloride extended-release) Prescribing Information. Bausch Health Companies Inc.
- Fava M, Rush AJ, Thase ME, et al. 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry. 2005;7(3):106-113.
- US Patent 6096341.
- US Patent 6143327.
- Modell JG, Rosenthal NE, Harriett AE, et al. Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. 2005;58(8):658-667.
- Ashton AK, Jamerson BD, Weinstein WL, Wagoner C. Antidepressant-related adverse effects impacting treatment compliance: results of a patient survey. Curr Ther Res Clin Exp. 2005;66(2):96-106.
- Kelly K, Posternak M, Alpert JE. Toward achieving optimal response: understanding and managing antidepressant side effects. Dialogues Clin Neurosci. 2008;10(4):409-418.
- Fortney JC, Pyne JM, Edlund MJ, et al. Reasons for antidepressant nonadherence among veterans treated in primary care clinics. J Clin Psychiatry. 2011;72(6):827-834.
- Hu XH, Bull SA, Hunkeler EM, et al. Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimate. J Clin Psychiatry. 2004;65(7):959-965.
- Gelenberg AJ, Freeman MP, Markowitz JC, et al. Practice guideline for the treatment of patients with major depressive disorder. 3rd ed. American Psychiatric Association; 2010.
- Clayton AH, Croft HA, Horrigan JP, et al. Bupropion extended release compared with escitalopram: effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies. J Clin Psychiatry. 2006;67(5):736-746.